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How Do Fatty Acids Cause Allosteric Binding of Drugs to Human Serum Albumin?

✍ Scribed by Victor Tuan Giam Chuang; Masaki Otagiri


Book ID
110396117
Publisher
Springer US
Year
2002
Tongue
English
Weight
269 KB
Volume
19
Category
Article
ISSN
0724-8741

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Binding of drugs to plasma proteins is an important determinant for their efficacy because it modulates drug availability to the intended target. Co-administered drugs may bind to the same protein site or to different functionally linked clefts following competitive and allosteric mechanisms. Here,