✦ LIBER ✦

Hot topic in hepatitis C virus research: The type of immunosuppression does not matter

✍ Scribed by Marina Berenguer

Book ID: 102933657
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 589 KB
Volume: 17
Category: Article
ISSN: 1527-6465
DOI: 10.1002/lt.22347

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✦ Synopsis

Key Points

The natural history of recurrent hepatitis C virus (HCV) is highly variable. Old donor age is a factor that has consistently been shown to affect disease progression. 2. Overall, immunosuppression determines the progression of HCV-related disease; however, the type of immunosuppressive agent used for induction or maintenance is not a key factor. 3. Steroid boluses should be avoided; they are associated with increased viremia, fibrosis progression, and reduced survival. 4. Antiviral therapy, particularly if it is successful, is associated with improved outcomes for liver transplant recipients with HCV. 5. There are no convincing data for modifying the type of immunosuppression before antiviral therapy is started.

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