1,2\_Bis(hydroxymethyl)ferrocene was oxidized by horse liver alcohol dehydrogenase preferentially to (lR, 2S)-(hydroxymethyl)aldehyd, while 1,2\_diformylferrocene was reduced to the (12, 2!)-antipode, The usefulness of enzymes as catalysts for asymmetric synthesis has been widely recognized. 1 Howe
Horse liver alcohol dehydrogenase-catalyzed enantioselective reduction of cyclic ketones: The effect of the hydrophobic side chain of the substrate on the stereoselectivity of the reaction
โ Scribed by Hajime Shigematsu; Toshihiko Matsumoto; Giichi Kawauchi; Yoshiki Hirose; Koichiro Naemura
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 466 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0957-4166
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## Abstract The effect of borane source on enantioselectivity in the enantiopure oxazaborolidineโcatalyzed asymmetric borane reduction of ketones has been investigated by using (__S__)โ3,1,2โoxazaborobicyclo[3.3.0]octane and (__S__)โ7,3,1,2โthiaxazaborobicyclo[3.3.0]octane as catalysts. The results