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Hormonal responses to 1,25-dihydroxyvitamin D3 in cultured mouse osteoblast-like cells—modulation by changes in receptor level

✍ Scribed by Theresa L. Chen; Janet M. Li; Todd Van Ye; Charlotte M. Cone; David Feldman


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
922 KB
Volume
126
Category
Article
ISSN
0021-9541

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✦ Synopsis


Department of Medicine, Stanford C / / i r ~ er\fl\ S c h o o l o l Medfcfne, S t d i T / o r d Ca/itorii/,r 94 HI5 The level o i l,2.510H)IDl receptors in ( ~i l t ~i i . 4 m o u w o.;teohl,i+likt~ t O l i ) cells is modulated Iiy t h v r,itt' 01 cell ~> r o l i l c ~t ' ~l i o i i .


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## Abstract 1α,25‐Dihydroxyvitamin D~3~ exerts rapid nongenomic effects on rat osteoblast‐like cells independent of the classic nuclear receptor. These effects include changes in phospholipid metabolism and cell calcium. Intracellular calcium itself has been proposed to regulate intracellular pH in

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## Abstract We have previously shown that one of the rapid nongenomic actions of 1α,25‐dihydroxyvitamin D~3~ (1α,25‐(OH)~2~D~3~), the increase in intracellular calcium (Ca^2+^), accompanies the increased osteocalcin (OC) mRNA steady‐state levels in rat osteosarcoma cells. To determine the functiona