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Hormonal Regulation of Estradiol 17β-Hydroxysteroid Dehydrogenase Activity in the ZR-75-1 Human Breast Cancer Cell Line

✍ Scribed by Catherine Thériault; Richard Poulin; Sandra Tremblay; Donald Poirier; Fernand Labrie

Book ID
119864897
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
135 KB
Volume
595
Category
Article
ISSN
0890-6564

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✍ M. Poutanen; V. Isomaa; K. Kainulainen; R. Vihko 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 643 KB

## Abstract Steroid regulation of 17β‐hydroxysteroid dehydrogenase (17‐HSD) was studied in the T‐47D human breast‐cancer cell line, using a radioimmunoassay. In addition, 3 mRNA species (2.4, 1.4, and 0.9 kb) specific for the enzyme were shown to be present in these cells. All the synthetic progest