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Homozygous intragenic loss of the WT1 locus in a sporadic intralobar wilms' tumor

✍ Scribed by Paolo Radice; Silvana Pilotti; Virna de Benedetti; Patrizia Mondini; Monia Miozzo; Roberto Luksch; Franca Fossati Bellani; Guiesppe Della Porta; Marco A. Pierotti


Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
346 KB
Volume
55
Category
Article
ISSN
0020-7136

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Wilms' tumor is a childhood nephroblastoma that is postulated to arise through the inactivation of a tumor suppressor gene by a two-hit mechanism. A candidate I I p I 3 Wilms' tumor gene, WTI. has been cloned and shown to encode a zinc finger protein. Patients with the WAGR syndrome (Wilms' tumor, a

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## Abstract We have analyzed the short arm of chromosome 1 using loss of heterozygosity (LOH) analysis in Wilms tumors (WT) to identify a minimal region of loss. 1909 WT, 22 malignant rhabdoid tumors of the kidney and 90 clear cell carcinomas of the kidney (CCSK) were subjected to LOH analysis usin

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