Communicated by R. G. H. Cotton We have examined a panel of 21 sporadic Wilms' tumours for rearrangements in the Wilms' tumour suppressor gene, WT1. In one tumour with specific allele loss in chromosome llp13, a homozygous deletion in the 3' end of the gene, encompassing exon 10 and the 3' untransla
Homozygous intragenic loss of the WT1 locus in a sporadic intralobar wilms' tumor
β Scribed by Paolo Radice; Silvana Pilotti; Virna de Benedetti; Patrizia Mondini; Monia Miozzo; Roberto Luksch; Franca Fossati Bellani; Guiesppe Della Porta; Marco A. Pierotti
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 346 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0020-7136
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Wilms' tumor is a childhood nephroblastoma that is postulated to arise through the inactivation of a tumor suppressor gene by a two-hit mechanism. A candidate I I p I 3 Wilms' tumor gene, WTI. has been cloned and shown to encode a zinc finger protein. Patients with the WAGR syndrome (Wilms' tumor, a
## Abstract We have analyzed the short arm of chromosome 1 using loss of heterozygosity (LOH) analysis in Wilms tumors (WT) to identify a minimal region of loss. 1909 WT, 22 malignant rhabdoid tumors of the kidney and 90 clear cell carcinomas of the kidney (CCSK) were subjected to LOH analysis usin
## Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Inci