Homovanillic acid in caudate and pre-frontal cortex following acute and chronic neuroleptic administration
โ Scribed by Malcolm B. Bowers; Frederick J. Hoffman
- Book ID
- 104716667
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 247 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Dose-response curves for the elevation of homovanillic acid (HVA) levels, determined by high performance liquid chromatography using electrochemical detection, in the pre-frontal cortex and caudate of rats after acute treatment with 12 antipsychotic drugs are presented. The order of potency in both
Phencyclidine (PCP) and d-amphetamine (AMP) had different effects upon homovanillic acid (HVA) levels in rat prefrontal cortex as compared to caudate. Lower doses of PCP increased HVA in prefrontal cortex only while lower doses of AMP decreased HVA in caudate alone. Higher doses of both drugs produc