Dose-response curves of homovanillic acid in pre-frontal cortex and caudate following antipsychotic drugs: relation to clinical potencies

✍ Scribed by W.-H. Chang; T.-Y. Chen; H.-S. Wu; W.-H. Hu; E.-K. Yeh

• Book ID: 104651192
• Publisher: Springer
• Year: 1988
• Tongue: English
• Weight: 364 KB
• Volume: 95
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00172955

✦ Synopsis

Dose-response curves for the elevation of homovanillic acid (HVA) levels, determined by high performance liquid chromatography using electrochemical detection, in the pre-frontal cortex and caudate of rats after acute treatment with 12 antipsychotic drugs are presented. The order of potency in both brain regions was: haloperidol>fluphenazine > loxapine > trifluoperazine > thiothixene > molindone > clopenthixol > chlorpromazine > metoclopramide > thioridazine > clozapine > sulpiride. This ranking is roughly correlated with that based on clinical potencies. The relative elevation of the content of HVA was weaker in the pre-frontal cortex than in the caudate for all drugs tested, except clozapine at a high dose.