Homology Modeling: Methods and Protocols

✍ Scribed by Antonina Andreeva (auth.), Andrew J. W. Orry, Ruben Abagyan (eds.)

Publisher: Humana Press
Year: 2012
Tongue: English
Leaves: 432
Series: Methods in Molecular Biology 857
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure. In, Homology Modelling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, Homology Modelling: Methods and Protocols guides scientists in the available homology modeling methods.

✦ Table of Contents

Front Matter....Pages i-xi
Back Matter....Pages 1-31
....Pages 33-54

✦ Subjects

Protein Science; Protein Structure

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