<p><p>Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an <i>in silico</i> method that predicts the tertiary structure of an amino acid sequence
Homology Modeling: Methods and Protocols
β Scribed by SΕawomir Filipek
- Publisher
- Springer Nature
- Year
- 2023
- Tongue
- English
- Leaves
- 379
- Category
- Library
No coin nor oath required. For personal study only.
β¦ Synopsis
This detailed volume provides state-of-the-art methodologies and reviews of important topics in the field of homology modeling. From homology modeling in the twilight zone and improving accuracy through sequence space analysis to approaches to construct multi-protein complex models, the book explores a wide variety of uses and applications of this valuable technique. Written for the highly successful Methods in Molecular Biology series, the chapters include introductions to their respective topics, lists of the necessary programs, webservers, and databases, step-by-step and readily reproducible protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Homology Modeling: Methods and Protocols serves as an ideal guide to recent homology modeling procedures, assumptions made, and model quality assessment that will illuminate the black box of homology modeling for novice readers and broaden the knowledge of this methodology for professionals.
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<p><p>Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an <i>in silico</i> method that predicts the tertiary structure of an amino acid sequence
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<DIV>This self-contained text is suitable for advanced undergraduate and graduate students and may be used either after or concurrently with courses in general topology and algebra. It surveys several algebraic invariants: the fundamental group, singular and Cech homology groups, and a variety of co
This self-contained text is suitable for advanced undergraduate and graduate students and may be used either after or concurrently with courses in general topology and algebra. It surveys several algebraic invariants: the fundamental group, singular and Cech homology groups, and a variety of cohomol