Polyamine amides are useful in gene delivery as synthetic (non-viral) vectors or mimics of polycationic histones. The application of a homologation strategy, based upon reductive alkylation, allows unsymmetrical polyamine amides to be prepared in good yield. The interaction of this polyamine amide w
Homologation of Polyamines in the Rapid Synthesis of Lipospermine Conjugates and Related Lipoplexes
β Scribed by Andrew J Geall; Ian S Blagbrough
- Book ID
- 104209833
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 697 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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## Homologation of Polyamines in the Synthesis of Lipo-Spermine Conjugates and Related Lipoplexes. -In continuation of efforts on the synthesis of polyamine amides useful in gene delivery as synthetic vectors or mimics of polycationic histones, the amides ( IV) and (VIII) are prepared. The synthe
Aryl-guanidino polyamine conjugates were prepared to evaluate their recognition for polyamine transporter (PAT) via a-difluoromethylornithine (DFMO) and spermidine (SPD)-treated B16 cell lines. The potent synergistic effects of DFMO on guanidino polyamine conjugates indicated that the presence of DF