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Homodimeric Tacrine Congeners as Acetylcholinesterase Inhibitors†

✍ Scribed by Hu, Ming-Kuan; Wu, Li-Ju; Hsiao, George; Yen, Mao-Hsiung


Book ID
115477315
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
70 KB
Volume
45
Category
Article
ISSN
0022-2623

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## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio