Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro
โ Scribed by J Wang; P Verdonk; D Elewaut; E.M Veys; G Verbruggen
- Book ID
- 114348622
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 161 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1063-4584
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## Abstract ## Objective Chondrocyte cell death may play an important role in the development of arthritis. The goal of the present study was to evaluate the role of the extracellular matrix (ECM) in promoting chondrocyte survival via signals through the integrin family of ECM receptors. ## Metho
We have recently described a 550,000-dalton nomollagenous cartilage matrix glycoprotein (CMGP), with subunits of 130,000, which is present in hyaline cartilage and fibrocartilage. Biosynthetic studies indicated that CMGP was synthesized by short-term organ cultures of normal canine articular cartila
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