Holothurinosides: New antitumour non sulphated triterpenoid glycosides from the sea cucumber holothuria forskalii.

✍ Scribed by Jaime Rodriguez; Rita Castro; Ricardo Riguera

• Book ID: 104204014
• Publisher: Elsevier Science
• Year: 1991
• Tongue: French
• Weight: 554 KB
• Volume: 47
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)86479-6

✦ Synopsis

Five triterpene glycosides (holothurinosides A, B, C and D; 1, 2, 3 and 5 respectively) and desholothurin A (4) have been isolated from the sea cucumber Holothuria forskalii. Compounds 1 and 2 are the first nonsulphated pentasaccharide saponins isolated from marine echinoderms. 3 and 5 are di and tetrasaccharides, and 4 is a tetrasaccharide that has been described as a synthetic intermediate. The structures were established by FAB-MS. COSY. NOESY and long range and direct XHCORR experiments, and selective hydrolysis. l-5 and the related saponin 6 have antitumour and antiviral activity, 1 and 4 being the most active with ICso values of 0.46 and 0.38 mg/ml respectively for P388 cells. DEPT CH CH CH CH CH2 CH CH CH CH CH CH3