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Holmes tremor: Application of modern neuroimaging techniques

✍ Scribed by Dominic C. Paviour; H. Rolf Jäger; Leonora Wilkinson; Marjan Jahanshahi; Andrew J. Lees

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
89 KB
Volume
21
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Holmes tremor has a characteristic rest, intention, and postural component. The syndrome arises as a consequence of a lesion in the upper brainstem and cerebral peduncles, which, it is postulated, interrupts the cerebello‐rubrothalamic pathway. Ataxia, ophthalmoplegia, and bradykinesia are associated features. We present a case of Holmes tremor secondary to a midbrain cavernoma. Modern neuroimaging techniques in this case confirm that a combination of damage to the cerebello‐rubrothalamic pathway and the nigrostriatal pathway is required for the full Holmes tremor syndrome to occur. © 2006 Movement Disorder Society

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