Ser326Cys polymorphism in the hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, has been identified and the variant genotype appears to be related to susceptibility to certain cancers. We investigated the association between Ser326Cys polymorphism and squamo
hOGG1 Ser326Cys polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population
โ Scribed by Qian Li; Lizhen Huang; Liucheng Rong; Yao Xue; Qin Lu; Yaoyao Rui; Jie Li; Na Tong; Meilin Wang; Zhengdong Zhang; Yongjun Fang
- Book ID
- 108587064
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 130 KB
- Volume
- 102
- Category
- Article
- ISSN
- 1347-9032
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## Abstract The human oxoguanine glycosylase 1(hOGG1) gene encodes a DNA glycosylase that is involved in excision repair of 8โOHโdG (8โhydroxyโ2โdeoxyguanine) from oxidativelyโdamaged DNA. To determine whether hOGG1 plays a role in the risk for adenocarcinoma of the gallbladder, we tested the assoc
## Abstract Oxidative stress is involved in many types of DNA damage, __e.g.,__ resulting in 8โhydroxyguanine adducts. Since a human counterpart exists for the yeast gene __OGG1__ (__hOGG1__) encoding an enzyme that repairs 8โhydroxyguanine, its polymorphism, Ser^326^Cys, might have potential as a