Hodgkin lymphoma in a mutated ZAP-70 negative B-cell Chronic Lymphocytic Leukemia patient
โ Scribed by Pasquale Niscola; Maria Ilaria Del Principe; Massimiliano Palombi; Stefano Fratoni; Daniela Piccioni; Luca Maurillo; Paolo de Fabritiis; Sergio Amadori; Giovanni Del Poeta
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 978 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0145-2126
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## Abstract Bโcell chronic lymphocytic leukemia (BโCLL) is characterized by a profound dysregulation of the host's immune system at both the humoral and cellular level. We investigated to see if this dysregulation could be due partly to thymus dysfunction by quantifying the number of signal joint T
## Abstract ## Background: Expression of T cell specific zetaโassociated protein 70 (ZAPโ70) by Bโcell chronic lymphocytic leukemia (BโCLL) cells, as investigated by flow cytometry, has both prognostic relevance and predictive power as surrogate for immunoglobulin heavy chain variable region (IgV~