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HMGB1, a potent proinflammatory cytokine in sepsis

โœ Scribed by Wenchang Huang; Yaoqing Tang; Lei Li


Book ID
116399443
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
338 KB
Volume
51
Category
Article
ISSN
1043-4666

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## Abstract High mobility __g__roup __b__ox 1 (HMGB1) is a chromatin protein that acts as an immunomodulatory cytokine upon active release from myeloid cells. HMGB1 is also an alarmin, an endogenous molecule released by dying cells that acts to initiate tissue repair. We have previously reported th