HLA supertypes and supermotifs: a functional perspective on HLA polymorphism

✍ Scribed by Alessandro Sette; John Sidney

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 663 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80124-6

✦ Synopsis

A large fraction of HLA class I, and possibly class II, molecules can be classified into relatively few supertypes, characterized by overlapping peptide-binding repertoires and consensus B-and F-pocket structures. Cross-binding peptides are frequently recognized by specific T cells in the course of natural disease processes and in the context of multiple HLA molecules, validating the concept of HLA supertypes at the functional level.