HLA Haplotype Sharing in Affected Siblings in Multiple Case Chinese Families with Thyrotoxicosis
β Scribed by S. H. Chan; P. P. B. Yeo; J. S. Cheah; P. Lim
- Book ID
- 115093083
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 90 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0001-2815
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π SIMILAR VOLUMES
The occurrence of multiple sclerosis (MS) in several members of families has been observed in 4.8% of 105 MS patients from a limited epidemiological area of Rostock. Typing of the HLA antigens in 4 affected sib-pairs showed two identical HLA haplotypes in 3 of the pairs: 1 pair shared one haplotype.
In diseases with a complex mode of inheritance, families with multiple affected individuals are difficult to ascertain. The haplotype sharing statistic (HSS) uses (hidden) co-ancestry between affected individuals from a founder population. These affected individuals will likely not only share the sa