HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
✍ Scribed by Todd, John A.; Bell, John I.; McDevitt, Hugh O.
- Book ID
- 109750822
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 756 KB
- Volume
- 329
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/329599a0
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
In this study HLA-DQA1 and TNF genes in addition to HLA-DQB1 gene were investigated at DNA level for elucidation of the genetic backgrounds of Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. DNA, amplified by polymerase chain reaction, was subjected to allele specific oligonucleot
Genes in the HLA complex are by far the most important in determining genetic predisposition or resistance to Type 1 (insulin-dependent) diabetes mellitus. In this review evidence is presented that the HLA genes mainly involved are those encoding some particular HLA-DQ molecules. Both among Black, C