𝔖 Bobbio Scriptorium
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HLA class II typing using oligonucleotide probes

✍ Scribed by David M. Robinson; Susan Holbeck; Christine Seyfried; Patricia Byers; Jerry Palmer; Gerald T. Nepom

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
286 KB
Volume
6
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

A DQf? locus-specific oligonucleotide probe is used to identify DQf? alleles present in six insulin-dependent diabetes mellitus (IDDM) multiplex families. Results of genotyping using this technique agree with those from cDNA probes and are often clearer. Allele-specific oligonucleotide probes for the DRf? locus are used to identify subtypes (Dw4 and Dw14) of the DR4 specificity in five IDDM multiplex families. This distinction cannot be made with available cDNA probes.

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