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Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer

✍ Scribed by Koji Matsumoto; Toshiharu Yasugi; Shunsuke Nakagawa; Mitsuo Okubo; Ranko Hirata; Hiroo Maeda; Hiroyuki Yoshikawa; Yuji Taketani

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 67 KB
Volume: 106
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.11332

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✦ Synopsis

The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty-seven women with HPV16-positive cervical cancer were analyzed for E6 sequence variation and its relationship to HLA class II alleles. Compared with local controls (n = 138) and published controls (n = 916), DRB1*1501 and DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 prototype (n = 11). Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16). Our observations suggest that a specific match between E6 variant proteins and HLA types may contribute to HPV16-related cervical carcinogenesis.

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