HLA Class II Antigens: A Comprehensive Review of Structure and Function

✍ Scribed by P. A. Peterson, L. Rask (auth.), Bjarte G. Solheim, Professor Erna Møller, Professor Soldano Ferrone (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1986
• Tongue: English
• Leaves: 579
• Edition: 1
• Category: Library

✦ Synopsis

This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans­ plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.

✦ Table of Contents

Front Matter....Pages I-XVII
Genes and Antigens of the HLA-D Region....Pages 1-13
Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression....Pages 14-31
Epitopes Are the Functional Units of HLA Class II Molecules and Form the Molecular Basis for Disease Susceptibility....Pages 32-48
Structure of Human Class II Antigens Expressed by a Homozygous Lymphoblastoid B Cell Line....Pages 49-70
The Complexity of HLA-DQ Molecules....Pages 71-82
HLA-DP: Current Status....Pages 83-108
Structural and Functional Studies of Mouse Class II Genes....Pages 109-127
Cross-reactions of Class II Histocompatibility Antigens of Various Species....Pages 128-153
Human Class II Antigen in Different Ethnic Groups....Pages 154-168
Serology of HLA Class II Antigens: Methodological Aspects....Pages 169-186
Alloantisera Against Human Class II Antigens: Definition and Methodology....Pages 187-203
Monoclonal Antibodies Against HLA Class II Antigens....Pages 204-223
Preparation, Characterization, and Utilization of Monoclonal Antibodies to the Gene Products of the HLA-D Region, with Special Emphasis on Those to Polymorphic Determinants....Pages 224-248
Cellular Detection of HLA Class II-Encoded Determinants: Subtype Polymorphisms of HLA-D....Pages 249-265
Cellular Detection of Human Class II MHC Antigens by Alloreactive T Cell Clones....Pages 266-280
Cellular Detection of Human Class II Antigens: Delineation of a Novel HLA-DP-like Suppressor Restriction System DY, the Sequential Expression of Class II Antigens, and a Pronounced Functional Flexibility of Class II Alloproliferative T Cell Clones....Pages 281-298
Modulation of Class II Antigens by Interferons....Pages 299-313
Changing Antigenic Profiles of HLA Class II Antigens on Activated T Cells and Their Biological Effects....Pages 314-338
Tissue Distribution of Class II Transplantation Antigens: Presence on Normal Cells....Pages 339-355
Class II MHC Antigens on Human Monocytes, Endothelial Cells, and Dendritic Cells....Pages 356-373
Class II Antigens: T Cells....Pages 374-385
Class II MHC Antigens and Hematopoiesis....Pages 386-401
Class II MHC Antigens and Erythropoiesis....Pages 402-411
Expression of Class II Antigens on Nonhematopoietic Tumor Cells....Pages 412-428
Class II HLA Antigens in Benign and Malignant Lesions of Melanocytic Origin....Pages 429-441
Molecular Polymorphism of Human Immune-Response-Genes....Pages 442-459
Molecular Genetics as a Tool in Clinical Transplantation....Pages 460-472
The Role of Human Class II Molecules in Activation of T4 Lymphocytes....Pages 473-488
Class II HLA Antigens in Autoimmune and Immune-Mediated Diseases....Pages 489-514
The Role of HLA Class II Antigens in Clinical Transplantation....Pages 515-529
Relevance of HLA-D/-DR Matching in a National Kidney Transplant Program....Pages 530-540
The Pig as a Model to Assess the Effect of Class II MHC Antigen Matching on Renal Allograft Survival....Pages 541-556
Back Matter....Pages 557-563

✦ Subjects

Allergology; Immunology