✦ LIBER ✦

HLA class I specific inhibitory receptors

✍ Scribed by Alessandro Moretta; Lorenzo Moretta

Book ID: 104358679
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 896 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80051-9

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✦ Synopsis

All human natural killer cells and some memory T cells express HLA class I receptors, so-called natural killer cell receptors (NKRs), a receptor class that in the past few years has been shown to include several members of the immunoglobulin superfamily and the C-type lectin CD94-NKG2A complex. NKR ligand mediated cross-linking leads to the recruitment and activation of a tyrosine phosphatase involved in downregulating the phosphorylation of effector molecules involved in cell triggering. Thus, NKR engagement leads to the inhibition of different NK and T cell functions.

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