HLA and IDDM predisposition: New aspects
✍ Scribed by Glenys Thomson; William Klitz; Edward J. Louis; Sing Kai Lo; Jörg Bertrams; Max Baur; Meinhard Neugebauer
- Book ID
- 102224590
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 349 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0741-0395
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📜 SIMILAR VOLUMES
The HLA DR genotype frequencies in insulin-dependent diabetes mellitus (IDDM) patients and the frequencies of DR alleles transmitted from affected parent to affected child both indicate that the DR3-associated predisposition is more "recessive'' and the DR4-associated predisposition more "dominant"
We previously proposed that the HLA-related genetic susceptibility to insulin dependent diabetes mellitus (IDDM) is best explained by at least two different susceptibility alleles, one preferentially associated with DR3, the other with DR4. This IDDM HLA heterogeneity model predicts that HLA haploty
## OBJECTIVE Our objective was to utilize a large extensively-typed ethnically-homogeneous set of IDDM families to investigate the relationship of alleles at loci in the HLA region to IDDM susceptibility. In particular, we wanted to examine the effects of DR alleles, since a recent study (Thomson