𝔖 Bobbio Scriptorium
✦   LIBER   ✦

HLA and insulin gene associations with IDDM

✍ Scribed by G. Thomson; W. P. Robinson; M. K. Kuhner; S. Joe; W. Klitz

Book ID
102224671
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
359 KB
Volume
6
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

The HLA DR genotype frequencies in insulin-dependent diabetes mellitus (IDDM) patients and the frequencies of DR alleles transmitted from affected parent to affected child both indicate that the DR3-associated predisposition is more "recessive'' and the DR4-associated predisposition more "dominant" in inheritance after allowing for the DR3iDR4 synergistic effect. B locus distributions on patient haplotypes indicate that only subsets of both DR3 and DR4 are predisposing. Heterogeneity is detected for both the DR3 and DR4 predisposing haplotypes based on DR genotypic class. With appropriate use of the family structure of the data a control population of "unaffected" alleles can be defined. Application of this method confirms the predisposing effect associated with the class 1 allele of the polymorphic region 5' to the insulin gene.

πŸ“œ SIMILAR VOLUMES

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✍ E. Bonifacio; G. A. Hitman πŸ“‚ Article πŸ“… 1995 πŸ› Springer 🌐 English βš– 260 KB

Letters to the editor chi-square value of 5 x 10 -4, (not significant). Comparison of the distribution of Cw7, B8, DR3, DQ2 haplotypes yields a chi-square value of 6 x 10 -3 (not significant). If HLA-A really does contribute to diabetes susceptibility in addition to the other loci on the extended HL

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Linkage analysis of HLA DR antigen as well as DR and DQ restriction fragment length polymorphism (RFLP) data using the LIPED computer program and various three-allele disease locus models showed very close linkage to an insulindependent diabetes mellitus (1DDM)-susceptibility locus. RFLP data alone