HL-A system in articular chondrocalcinosis

✍ Scribed by Š. Nyulassy; Dr. J. Štefanovič; Dr. Š. Siťaj; Dr. D. Žitňan

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 183 KB
• Volume: 19
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/1529-0131(197605/06)19:3+<391::aid-art1780190711>3.0.co;2-#

✦ Synopsis

The associations of several disease entities in rheumatology with the human major histocompatibility system-the HL-A system-are well knDwn; as a review see for example Ryder et a1 (1 ). Although the regulatory functions of this system, the most complex and polymorphic known genetic system of mar., are concerned particularly with immune reactivity, vitrious other important traits (for example several enz:imes) also seem to be involved. These have led the present authors to investigate the relationship between the I-IL-A system and a metabolic disorder-chondrocalcinoris (2,3).

Methods

Two groups of patients were inbestigated. Twelve patients from 7 families from a Southwest S ovak locality with endemic occurrence of familial form of chondrocalcinosis and 13 unrelated individuals suffering from chondrocalcinosis from all over Slovakia; 19 healthy family members and 314 healthy unretated persons respectively 'were the control groups.

Nine antigens of the first locus and IS antigens of the second locus of the HL-A system were determined with mono-