The associations of several disease entities in rheumatology with the human major histocompatibility system-the HL-A system-are well knDwn; as a review see for example Ryder et a1 (1 ). Although the regulatory functions of this system, the most complex and polymorphic known genetic system of mar., a
β¦ LIBER β¦
Articular chondrocalcinosis in a dutch pedigree
β Scribed by Dr. Jan K. Van Der Korst; Jos. Geerards
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 341 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0004-3591
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## Abstract A gene in the heterozygous state appears responsible for a 2βfold increase in pyrophosphate content of both fibroblasts and lymphoblasts cultured from patients who have dominantly inherited chondrocalcinosis. Cells from unaffected family members of this large kindred showed a pyrophosph