HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements

Drug resistance mutations and newly reco

Drug resistance mutations and newly recognized treatment-related substitutions in the HIV-1 protease gene: Prevalence and associations with drug exposure and real or virtual phenotypic resistance to protease inhibitors in two clinical cohorts of antiretroviral experienced patients

✍ Carlo Torti; Eugenia Quiros-Roldan; Laura Monno; Andrea Patroni; Annalisa Saraci 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

## Abstract This study aimed at identifying HIV‐1 protease amino acid changes associated with protease inhibitor (PI) exposure and susceptibility. New amino acid substitutions were correlated with the number of experienced PIs, reaching statistical significance only for those at positions 3, 44, an