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HIV-1 Envelope Glycoprotein gp120 Does Not Bind to Galactosylceramide-Expressing Rat Oligodendrocytes

✍ Scribed by Eric Parmantier; Madeleine Monge; Micaël Yagello; Florence Cabon; Corinne Demerens; Jean-Claude Gluckman; Bernard Zalc


Book ID
112270256
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
566 KB
Volume
206
Category
Article
ISSN
0042-6822

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HIV-l-associated cognitive/motor complex is one of the major neurological complications of AIDS and is associated with neuronal loss. Gp120, the HIV envelope protein, is toxic for neurons in cultures and produces a rise in intracytosolic calcium. This neurotoxicity is dose-dependent and time-depende