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In vivo alteration of humoral responses to HIV-1 envelope glycoprotein gp120 by antibodies to the CD4-binding site of gp120

โœ Scribed by Maria Luisa Visciano; Michael Tuen; Miroslaw K. Gorny; Catarina E. Hioe


Book ID
113947409
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
707 KB
Volume
372
Category
Article
ISSN
0042-6822

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The mechanisms accounting for T cell depletion in AIDS patients are not yet fully understood, nor are the roles of host factors in HIV pathogenesis. We show here that an ongoing humoral immune response to HIV gp120 can sensitize non-infected cells towards apoptosis. Thus, i.v. injection of 1 ? g rec