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Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

✍ Scribed by Kurtis E Bachman; Ben Ho Park; Ina Rhee; Harith Rajagopalan; James G Herman; Stephen B Baylin; Kenneth W Kinzler; Bert Vogelstein


Book ID
114413259
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
343 KB
Volume
3
Category
Article
ISSN
1535-6108

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## Abstract The identification of molecules that are down‐regulated in malignant phenotype is important for understanding tumor biology and their role in tumor suppression. We compared the expression profile of four normal nasal mucosal (NNM) epithelia and a series of nasopharyngeal cancinoma (NPC)