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Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas

✍ Scribed by Yutaka Kondo; Lanlan Shen; Seiji Suzuki; Tsuyoshi Kurokawa; Kazuo Masuko; Yasuhito Tanaka; Hideaki Kato; Yoshiki Mizuno; Masamichi Yokoe; Fuminaka Sugauchi; Noboru Hirashima; Etsuro Orito; Hirotaka Osada; Ryuzo Ueda; Yi Guo; Xinli Chen; Jean-Pierre J. Issa; Yoshitaka Sekido

Book ID
118087839
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
197 KB
Volume
37
Category
Article
ISSN
1386-6346

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DNA methylation and histone modification
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## Abstract Secreted frizzled‐related protein 2 (__sFRP2__) is a negative modulator of the Wingless‐type (Wnt) signaling pathway, and shown to be inactivated in renal cell carcinoma (RCC). However, the molecular mechanism of silencing of __sFRP2__ is not fully understood. Our study was designed to