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Histone H1° Ribosomal RNA Synthesis and Cell Differentiation

✍ Scribed by R.A. Flickinger

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
107 KB
Volume
196
Category
Article
ISSN
0022-5193

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✦ Synopsis

It is proposed that histone H1°prevents binding of the rRNA transcription factor UBF to regulatory sequences of the rRNA gene. This has a role in reducing rRNA synthesis and inhibiting cell proliferation. This affords the opportunity for other mechanisms to promote cell differentiation.

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