Histone Deacetylases: Transcriptional Regulation and other Cellular Functions
β Scribed by Garcia-Manero, G
- Book ID
- 109999120
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 41 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0007-0920
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π SIMILAR VOLUMES
A key event in the regulation of eukaryotic gene expression is the posttranslational modification of nucleosomal histones, which converts regions of chromosomes into transcriptionally active or inactive chromatin. The most well studied posttranslational modification of histones is the acetylation of
## Abstract Transcriptional repression and silencing have been strongly associated with hypoacetylation of histones. Accordingly, histone deacetylases, which remove acetyl groups from histones, have been shown to participate in mechanisms of transcriptional repression. Therefore, current models of