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Histone Deacetylase Inhibitors

✍ Scribed by Thomas A. Miller; David J. Witter; Sandro Belvedere

Publisher
John Wiley and Sons
Year
2004
Weight
53 KB
Volume
35
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

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## Abstract Histone deacetylase (HDAC), inhibitors represent a new class of targeted anti‐cancer agents. Several of these compounds are in clinical trials with significant activity against a spectrum of both hematologic and solid tumors at doses that are well tolerated by the patients. The HDAC inh

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## Abstract In cancer cells, an imbalance often exists between histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities, and various drug companies are actively seeking competitive HDAC inhibitors for chemotherapeutic intervention. Cancer cells appear to be more sensitive than nont