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Histone deacetylase inhibitors: discovery and development as anticancer agents

✍ Scribed by Marks, Paul A; Dokmanovic, Milos


Book ID
121251729
Publisher
Informa plc
Year
2005
Tongue
English
Weight
275 KB
Volume
14
Category
Article
ISSN
1354-3784

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## Abstract In cancer cells, an imbalance often exists between histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities, and various drug companies are actively seeking competitive HDAC inhibitors for chemotherapeutic intervention. Cancer cells appear to be more sensitive than nont