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Histone deacetylase inhibitors as anti-neoplastic agents

โœ Scribed by Nicolas Batty; Gabriel G. Malouf; Jean Pierre J. Issa


Book ID
116335203
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
215 KB
Volume
280
Category
Article
ISSN
0304-3835

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## Abstract In cancer cells, an imbalance often exists between histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities, and various drug companies are actively seeking competitive HDAC inhibitors for chemotherapeutic intervention. Cancer cells appear to be more sensitive than nont