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196 HISTONE DEACETYLASE INHIBITORS AS CHONDROPROTECTIVE AGENTS

โœ Scribed by K.L. Culley; S. Fenwick; I. Clark

Book ID
114351407
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
40 KB
Volume
17
Category
Article
ISSN
1063-4584

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## Abstract In cancer cells, an imbalance often exists between histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities, and various drug companies are actively seeking competitive HDAC inhibitors for chemotherapeutic intervention. Cancer cells appear to be more sensitive than nont