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Histone deacetylase inhibitor valproic acid suppresses the growth and increases the androgen responsiveness of prostate cancer cells

✍ Scribed by Yu-Wei Chou; Nagendra K. Chaturvedi; Shougiang Ouyang; Fen-Fen Lin; Dharam Kaushik; Jue Wang; Isaac Kim; Ming-Fong Lin

Book ID: 116335719
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 904 KB
Volume: 311
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2011.07.015

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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th