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Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites

✍ Scribed by Soyoung Kim; Jae Ku Kang; Yong Kee Kim; Dong-Wan Seo; Seong Hoon Ahn; Jae Cheol Lee; Chang-Hee Lee; Jueng-Soo You; Eun-Jung Cho; Hyang Woo Lee; Jeung-Whan Han


Book ID
116292451
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
283 KB
Volume
342
Category
Article
ISSN
0006-291X

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## Abstract The histone deacetylase (HDAC) inhibitors are an exciting new class of drugs that are targeted as anti‐cancer agents. These compounds can induce growth arrest, apoptosis, and/or terminal differentiation in a variety of cancers. The inhibition of HDACs shifts toward hyper‐acetylation, th