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Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice

โœ Scribed by Dovey, Oliver M; Vasilliou, George; Bradley, Allan; Cowley, Shaun M


Book ID
121628996
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
80 KB
Volume
5
Category
Article
ISSN
1868-7075

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Histone deacetylase inhibitor-induced expression of p21 WAF1 is p53 independent. In the present study, we provide evidence that trichostatin A (TSA), a specific inhibitor of histone deacetylase, can elevate H3 and H4 acetylation and p21 WAF1 expression in NIH3T3 cells at first. To identify the trans