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Histone deacetylase as a therapeutic target

✍ Scribed by Oliver H. Krämer; Martin Göttlicher; Thorsten Heinzel


Book ID
117699882
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
623 KB
Volume
12
Category
Article
ISSN
1043-2760

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Histone deacetylases (HDACs) are enzymes that cleave off acetyl groups from acetyl-lysine residues in histones and various nonhistone proteins. Four different classes of HDACs have been identified in humans so far. Although classes I, II, and IV are zinc-dependent amidohydrolases, class III HDACs de