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Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation

✍ Scribed by Gregory D. Conway; Melanie A. O'Bara; Bansi H. Vedia; Suyog U. Pol; Fraser J. Sim

Book ID
115556079
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
552 KB
Volume
60
Category
Article
ISSN
0894-1491

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## Abstract Mammalian development requires commitment of cells to restricted lineages, which requires epigenetic regulation of chromatin structure. Epigenetic modifications were examined during in vitro differentiation of murine embryonic stem (ES) cells. Global histone acetylation, a euchromatin m