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Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

✍ Scribed by Christian A Hassig; Tracey C Fleischer; Andrew N Billin; Stuart L Schreiber; Donald E Ayer

Book ID
117267213
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
153 KB
Volume
89
Category
Article
ISSN
0092-8674

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Histone deacetylase activity is required
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## Abstract Mammalian development requires commitment of cells to restricted lineages, which requires epigenetic regulation of chromatin structure. Epigenetic modifications were examined during in vitro differentiation of murine embryonic stem (ES) cells. Global histone acetylation, a euchromatin m