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Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis

✍ Scribed by Hossein Hemmatazad; Hanna Maciejewska Rodrigues; Britta Maurer; Fabia Brentano; Margarita Pileckyte; Jörg H. W. Distler; Renate E. Gay; Beat A. Michel; Steffen Gay; Lars C. Huber; Oliver Distler; Astrid Jüngel


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
312 KB
Volume
60
Category
Article
ISSN
0004-3591

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## Abstract Histone deacetylases (HDACs) are involved in chromatin remodeling and modification of nonhistone transcription regulatory proteins, thus modulating the expression of genes important for complex biological events. Dysregulation of HDACs and aberrant chromatin acetylation and deacetylatio