Histologic evaluation of L1210 leukemia in treated and untreated mice

✍ Scribed by Richard T. Glass; Edwin C. Glassell; Jerald J. Killion; G. Mark Kollmorgen

• Book ID: 104660377
• Publisher: Springer-Verlag
• Year: 1977
• Tongue: English
• Weight: 546 KB
• Volume: 2
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00199091

✦ Synopsis

BDFI mice bearing L1210 leukemia were treated with chemotherapy or in combination with neuraminidase-treated cells and BCG. Histological evaluation was done on these mice at various intervals after therapy in order to determine the rate and extent of metastatic involvement in various tissues and organs. Results were compared to tumor-bearing mice which were not treated. In all animals, tissues were classed as having minimal involvement, moderate involvement or maximal involvement based on a scale of 0 through 4. Results indicated that: (a) mice which were long term survivors did not completely reject t~eir tumor for weeks after treatment with chemotherapy and immunotherapy; (b) complete tumor rejection did not indicate a restoration of normal tissue integrity; and (e) failure of ehemotherapy-immunotherapy had no consistent pathology, but was probably due to tumor distribution rather then tumor burden per se.