Histogenesis and cell lineage analysis of medulloblastomas
β Scribed by Merit Cudkowicz; Suzanne M. De la Monte
- Book ID
- 118930872
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 924 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0022-510X
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## Abstract Brain tumors are the second most common childhood cancer. We used highβresolution array comparative genomic hybridization (aCGH) to analyze losses and gains of genetic material from 24 medulloblastomas. The bacterial artificial chromosome clones were ordered on the array, allowing for a
## Abstract Our group has previously demonstrated a high frequency of allelic loss on the short arm of chromosome 8 and identified a region of homozygous deletion of 1.41 Mb, flanked by D8S520 and D8S1130, on 8p23.1 in medulloblastomas, suggesting the presence of a tumor suppressor gene in this cri