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Histochemical investigation of adjuvant-induced arthritis

✍ Scribed by Fred R. Nusbickel; Henry Troyer


Book ID
102749926
Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
698 KB
Volume
19
Category
Article
ISSN
0004-3591

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✦ Synopsis


Abstract

Rats with adjuvant‐induced arthritis were observed to have increased alkaline phosphatase, acid phosphatase (two isozymes), and ATPase activity in the radial zone of articular cartilage, at the osteochondral junction, and in the bone marrow elements. A qualitative and quantitative reduction of azure A, PAS, colloidal iron, alcian blue critical electrolyte concentration staining (0.4 and 0.9 M (mg Cl~2~) was also observed in corresponding areas. These findings suggest the degradation of the articular cartilage matrix with possible simultaneous or resultant calcification.


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✍ Grant W. Cannon; Marie M. Griffiths; Marion L. Woods πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 431 KB πŸ‘ 2 views

Objective. To define the effects of incomplete Freund's adjuvant (LCFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type I1 collagen (CII) in DA and Lewis rats. Methods. ICFA was injected into DA and Lewis rats before CFA or CII injection. Results. DA rats previously in